PD-L1: Biological mechanism, function, and immunotherapy in gastric cancer

PD-L1: Biological mechanism, function, and immunotherapy in gastric cancer

Blog Article

Gastric cancer (GC) is one of the main causes of cancer incidence rate and mortality worldwide.As the main breakthrough direction, the application of immune checkpoint inhibitors makes patients with GC have better prognosis, where PD-L1/PD-1 inhibitors in immunotherapy have good anti-tumor immune efficacy.Further understanding of the regulatory mechanism of PD-L1 in GC may bring substantial progress to the A Guide to Opportunities and Challenges of Developing a Virtual Reality Simulation for Disaster Medicine Courses: A Letter to Editor immunotherapy.

In this review, we provide information on the endogenous and exogenous regulatory mechanisms of PD-L1 and its biological functions combined with current clinical trials of PD-L1/PD-1 inhibitors in GC.The malignant biological phenotypes caused by PD-L1 and the corresponding clinical combined treatment scheme have been reported.Identifying the biomarkers of the potential efficacy of immunotherapy and specifying the clinical immunotherapy scheme in combination with molecular characteristics of patients may maximize clinical Competences of the emergency nurse and the product of nursing care: an integrative review benefits and better prognosis.